Miami Open: Novak Djokovic out with elbow injury
Djokovic, who has won a record-tying six titles in Miami, was beaten by Australian Nick Kyrgios last week in the fourth round at Indian Wells, marking his second loss to the Australian in less than two weeks.
Murray has struggled to get going in most of his tournaments this season.
Andy Murray has withdrawn from the upcoming Miami Open due to a right elbow injury. It's one of my favourite tournaments. "The focus now is getting ready for the claycourt season".
With the top seed's departure, world number 136 Taylor Fritz, the 19-year-old American, will take his place in the main draw.
Briton Murray will extend his lead at the top of the world rankings to more than 4,000 points as Djokovic will lose the points he earned from winning in Miami previous year. Top-ranked Serena Williams, an eight-time champions at the event, will also miss it this year, citing a knee injury.
Djokovic's withdrawal from Miami is just the latest setback for a player who endured a drop in form after completing the career Grand Slam with a long-sought French Open victory previous year. The newspaper reports Djokovic travelled from Indian Wells to Monaco on Friday to have the injury assessed by his doctor.
"Sadly, due to a right elbow injury, I won't be playing in Miami", Murray said in a statement that caught even his own team by surprise.
Novak Djokovic will not defend his Miami Open title.